Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 5 Reviews
8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
667 mcg DFE (400 mcg Folic Acid)
167%
Calcium (as Calcium Carbonate)
100 mg
8%
Top Medical Research Studies
9
We explored the effects of methotrexate (MTX), a well-known folic acid antagonist, in addressing epidural fibrosis (EF), a common complication that can lead to persistent back pain after lumbar surgery. In our study, we tested how topical application of MTX influenced the healing process following lumbar laminectomy in rats, an experimental model for understanding back pain post-surgery.
Our results were promising—the use of MTX seemed to significantly suppress the development of EF compared to the control group. We measured this through various methods, including macroscopic scoring, hydroxyproline content analysis, and histological evaluations. Additionally, we observed that the effectiveness of MTX was dose-dependent, increasing with higher concentrations.
We also investigated the underlying mechanisms and found that the effects of MTX might be linked to endoplasmic reticulum (ER) stress, which appeared to trigger cell apoptosis in fibroblasts. This suggests that MTX could potentially help in regulating scar formation which is often at the root of chronic back pain.
Overall, our findings indicate that while MTX does not target folate directly, its therapeutic properties may offer a new avenue for managing post-surgical back pain through its effects on EF and associated cellular pathways.
Our results were promising—the use of MTX seemed to significantly suppress the development of EF compared to the control group. We measured this through various methods, including macroscopic scoring, hydroxyproline content analysis, and histological evaluations. Additionally, we observed that the effectiveness of MTX was dose-dependent, increasing with higher concentrations.
We also investigated the underlying mechanisms and found that the effects of MTX might be linked to endoplasmic reticulum (ER) stress, which appeared to trigger cell apoptosis in fibroblasts. This suggests that MTX could potentially help in regulating scar formation which is often at the root of chronic back pain.
Overall, our findings indicate that while MTX does not target folate directly, its therapeutic properties may offer a new avenue for managing post-surgical back pain through its effects on EF and associated cellular pathways.
Read More
Most Useful Reviews
9
Alleviates PMS pain
After a month of use, back pain during menstruation disappeared and I take these courses periodically.
Read More
7.5
Reduces back pain
6 people found this helpful
Excellent! It really helps my back pain when taken with B12 from 21st Century, great quality and price. Folic acid helps reduce the risk of neural tube deficiencies affecting the brain and spine during pregnancy. Please help me with a like, blessings in your life!🙏🌻
Read More
7.5
Relieves back pain
Folic acid has improved my appearance, with nails no longer peeling, fresher skin, and less hair loss. It also greatly alleviates the back pain associated with PMS. I recommend this vitamin to everyone, including men.
Read More
Medical Researches
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
- All Researches
9
We explored the effects of methotrexate (MTX), a well-known folic acid antagonist, in addressing epidural fibrosis (EF), a common complication that can lead to persistent back pain after lumbar surgery. In our study, we tested how topical application of MTX influenced the healing process following lumbar laminectomy in rats, an experimental model for understanding back pain post-surgery.
Our results were promising—the use of MTX seemed to significantly suppress the development of EF compared to the control group. We measured this through various methods, including macroscopic scoring, hydroxyproline content analysis, and histological evaluations. Additionally, we observed that the effectiveness of MTX was dose-dependent, increasing with higher concentrations.
We also investigated the underlying mechanisms and found that the effects of MTX might be linked to endoplasmic reticulum (ER) stress, which appeared to trigger cell apoptosis in fibroblasts. This suggests that MTX could potentially help in regulating scar formation which is often at the root of chronic back pain.
Overall, our findings indicate that while MTX does not target folate directly, its therapeutic properties may offer a new avenue for managing post-surgical back pain through its effects on EF and associated cellular pathways.
Our results were promising—the use of MTX seemed to significantly suppress the development of EF compared to the control group. We measured this through various methods, including macroscopic scoring, hydroxyproline content analysis, and histological evaluations. Additionally, we observed that the effectiveness of MTX was dose-dependent, increasing with higher concentrations.
We also investigated the underlying mechanisms and found that the effects of MTX might be linked to endoplasmic reticulum (ER) stress, which appeared to trigger cell apoptosis in fibroblasts. This suggests that MTX could potentially help in regulating scar formation which is often at the root of chronic back pain.
Overall, our findings indicate that while MTX does not target folate directly, its therapeutic properties may offer a new avenue for managing post-surgical back pain through its effects on EF and associated cellular pathways.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Alleviates PMS pain
After a month of use, back pain during menstruation disappeared and I take these courses periodically.
Read More
7.5
Reduces back pain
6 people found this helpful
Excellent! It really helps my back pain when taken with B12 from 21st Century, great quality and price. Folic acid helps reduce the risk of neural tube deficiencies affecting the brain and spine during pregnancy. Please help me with a like, blessings in your life!🙏🌻
Read More
7.5
Relieves back pain
Folic acid has improved my appearance, with nails no longer peeling, fresher skin, and less hair loss. It also greatly alleviates the back pain associated with PMS. I recommend this vitamin to everyone, including men.
Read More
7.5
Eases chest pain
2 people found this helpful
Recommended by my doctor for chest pain, when taken with vitamin E, it was quite effective.
Read More
2
Causes stomach pain
My son tolerates this well, though it causes stomach pain even when taken on a full stomach, which I did not experience with other folic preparations.
Read More
Frequently Asked Questions
9
Alleviates PMS pain
After a month of use, back pain during menstruation disappeared and I take these courses periodically.
7.5
Relieves back pain
Folic acid has improved my appearance, with nails no longer peeling, fresher skin, and less hair loss. It also greatly alleviates the back pain associated with PMS. I recommend this vitamin to everyone, including men.
7.5
Reduces back pain
6 people found this helpful
Excellent! It really helps my back pain when taken with B12 from 21st Century, great quality and price. Folic acid helps reduce the risk of neural tube deficiencies affecting the brain and spine during pregnancy. Please help me with a like, blessings in your life!🙏🌻
2
Causes stomach pain
My son tolerates this well, though it causes stomach pain even when taken on a full stomach, which I did not experience with other folic preparations.
7.5
Eases chest pain
2 people found this helpful
Recommended by my doctor for chest pain, when taken with vitamin E, it was quite effective.
9
We explored the effects of methotrexate (MTX), a well-known folic acid antagonist, in addressing epidural fibrosis (EF), a common complication that can lead to persistent back pain after lumbar surgery. In our study, we tested how topical application of MTX influenced the healing process following lumbar laminectomy in rats, an experimental model for understanding back pain post-surgery.
Our results were promising—the use of MTX seemed to significantly suppress the development of EF compared to the control group. We measured this through various methods, including macroscopic scoring, hydroxyproline content analysis, and histological evaluations. Additionally, we observed that the effectiveness of MTX was dose-dependent, increasing with higher concentrations.
We also investigated the underlying mechanisms and found that the effects of MTX might be linked to endoplasmic reticulum (ER) stress, which appeared to trigger cell apoptosis in fibroblasts. This suggests that MTX could potentially help in regulating scar formation which is often at the root of chronic back pain.
Overall, our findings indicate that while MTX does not target folate directly, its therapeutic properties may offer a new avenue for managing post-surgical back pain through its effects on EF and associated cellular pathways.
Our results were promising—the use of MTX seemed to significantly suppress the development of EF compared to the control group. We measured this through various methods, including macroscopic scoring, hydroxyproline content analysis, and histological evaluations. Additionally, we observed that the effectiveness of MTX was dose-dependent, increasing with higher concentrations.
We also investigated the underlying mechanisms and found that the effects of MTX might be linked to endoplasmic reticulum (ER) stress, which appeared to trigger cell apoptosis in fibroblasts. This suggests that MTX could potentially help in regulating scar formation which is often at the root of chronic back pain.
Overall, our findings indicate that while MTX does not target folate directly, its therapeutic properties may offer a new avenue for managing post-surgical back pain through its effects on EF and associated cellular pathways.
References
- Chen H, Yan L, Wang J, Sun Y, Li X, et al. Methotrexate prevents epidural fibrosis through endoplasmic reticulum stress signalling pathway. Eur J Pharmacol. 2017;796:131. 10.1016/j.ejphar.2016.12.032
